Planar Polarity: Converting a Morphogen Gradient into Cellular Polarity
نویسندگان
چکیده
منابع مشابه
Planar Polarity: Converting a Morphogen Gradient into Cellular Polarity
Epithelial cells are polarized within the apico-basal and planar axes. The latter - planar cell polarity - requires long-range regulation of orientation as well as short-range, cell-to-cell realignment through feedback loops. New insights into the long-range, gradient-type regulation reveal how a kinase translates the morphogen gradient input into cellular orientation.
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Epithelial cells frequently display--in addition to the common apical-basolateral polarity--a polarization within the plane of the epithelium. This is commonly referred to as planar cell polarity (PCP) or tissue polarity. Examples of vertebrate PCP include epithelial patterning in the skin and inner ear, and also the morphogenetic movements of mesenchymal cells during convergent extension at ga...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2015
ISSN: 0960-9822
DOI: 10.1016/j.cub.2015.03.011